TY - JOUR T1 - Methicillin-resistant Staphylococcus aureus isolated from an intensive care unit in Minas Gerais, Brazil, over a six-year period JO - The Brazilian Journal of Infectious Diseases T2 - AU - Nascimento,Thiago C. AU - Diniz,Cláudio G. AU - Silva,Vânia L. AU - Ferreira-Machado,Alessandra B. AU - Fajardo,Marina O. AU - de Oliveira,Tamara Lopes R. AU - Ferreira,Dennis de C. AU - Cavalcante,Fernanda S. AU - Santos,Kátia R. Netto dos SN - 14138670 M3 - 10.1016/j.bjid.2017.10.004 DO - 10.1016/j.bjid.2017.10.004 UR - https://www.bjid.org.br/en-methicillin-resistant-staphylococcus-aureus-isolated-from-articulo-S1413867017307742 AB - To characterize methicillin-resistant Staphylococcus aureus isolates from an intensive care unit of a tertiary-care teaching hospital, between 2005 and 2010. A total of 45 isolates were recovered from patients admitted to the intensive care unit in the study period. Resistance rates higher than 80% were found for clindamycin (100%), erythromycin (100%), levofloxacin (100%), azithromycin (97.7%), rifampin (88.8%), and gentamycin (86.6%). The SCCmec typing revealed that the isolates harbored the types III (66.7%), II (17.8%), IV (4.4%), and I (2.2%). Four (8.9%) isolates carried non-typeable cassettes. Most (66.7%) of the isolates were related to the Brazilian endemic clone from CC8/SCCmec III, which was prevalent (89.3%) between 2005 and 2007, while the USA100/CC5/SCCmec II lineage emerged in 2007 and was more frequent in the last few years. The study showed high rates of antimicrobial resistance among methicillin-resistant S. aureus isolates and the replacement of Brazilian clone, a well-established hospital lineage, by the USA100 in the late 2000s, at the intensive care unit under study. ER -