TY - JOUR T1 - Impact of A/H1N1 influenza in children at a Brazilian University Hospital JO - The Brazilian Journal of Infectious Diseases T2 - AU - Biondo,Gabriela Fontanella AU - Santana,João Carlos AU - Lago,Patrícia M. AU - Piva,Jefferson AU - Souza,Paulo Ricardo A. AU - Gaulke,Joana Genz AU - Sebben,Juliana M. SN - 14138670 M3 - 10.1016/j.bjid.2018.05.004 DO - 10.1016/j.bjid.2018.05.004 UR - https://www.bjid.org.br/en-impact-a-h1n1-influenza-in-children-articulo-S1413867017310498 AB - BackgroundA/H1N1 influenza is a viral disease that affects a significant part of the population mainly in winter, leading to increased number of medical consultations, hospitalizations and consequently care spending in emergency. MethodsThis is a case-series retrospective study, involving patients admitted to a tertiary hospital in southern Brazil in 2016 with a clinical diagnosis of acute respiratory infection of the influenza type and laboratory confirmation of influenza A/H1N1. Results64 patients were included, mostly male, median age of 48.3 months. Chronic underlying diseases were found in 73% of the patients, and these patients evolved to the most unfavorable outcome. About vaccination, of the 57 patients with an age range for vaccination, only 28% had complete vaccination coverage. The main clinical manifestations found in the included patients were fever, cough, intercostal indrawing, wheezing, tachypnea and pulmonary crackles. These patients were mainly followed-up with laboratory tests and chest X-ray. Consolidation was evident in 43% of patients followed by interstitial infiltrate in 33%. A five-day course of neuraminidase inhibitor was prescribed for all patients, as recommended by the WHO, but due to the complications, 73% of the patients required antibiotic therapy, and 61% oxygen therapy. The majority of patients had a favorable outcome, but 11 required intensive care and one died. ConclusionsA/H1N1 influenza persists as an important public health problem, mainly due to high morbidity and hospitalization rates. It is important to identify patients with A/H1N1 influenza and clinical situations with higher risk of complications. Through this study, it is possible to analyze the characteristics of pediatric patients with A/H1N1 influenza and mainly to emphasize assistance of populations with comorbidities, since they present higher rates of complications and death. ER -