Journal Information
Vol. 15. Issue 6.
Pages 601-606 (November - December 2011)
Share
Share
Download PDF
More article options
Vol. 15. Issue 6.
Pages 601-606 (November - December 2011)
Original article
Open Access
Immune reconstitution inflammatory syndrome associated with pulmonary sarcoidosis in an HIV-infected patient: an immunohistochemical study
Visits
2626
Érique José Peixoto de Miranda1,*, Olavo Henrique Munhoz Leite2, Maria Irma Seixas Duarte3
1 Resident Physician, Department of Infectious Diseases, Medical School, Universidade de São Paulo (USP), SP, Brazil
2 Department of Infectious Diseases, Medical School, USP, Brazil
3 Department of Pathology, Medical School, USP, Brazil
This item has received

Under a Creative Commons license
Article information
Abstract

Sarcoidosis has been rarely described in literature as a cause of interstitial pulmonary disease associated with AIDS. This study reports a case of immune reconstitution inflammatory syndrome associated with pulmonary sarcoidosis in a patient with a history of previous pulmonary tuberculosis concomitant with HIV infection. Results of the immunohistochemical study of samples from the resected right lower lobe are described. Pathological findings suggest a role of Th1, Th2 and Th17 response in IRIS associated sarcoidosis.

Keywords:
acquired immunodeficiency syndrome
sarcoidosis, pulmonary
immune reconstitution inflammatory syndrome
immunohistochemistry
Full text is only aviable in PDF
References
[1.]
Almeida F.A. Jr., F.J.S. Sager, G. Eiger.
Coexistent sarcoidosis and HIV infection: an immunological paradox?.
J Infect, 52 (2006), pp. 195-201
[2.]
D.G. Morris, R.M. Jasmer, L. Huang, et al.
Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence.
Chest, 124 (2003), pp. 929-935
[3.]
M.A. French.
Immune Reconstitution Inflammatory Syndrome: A Reappraisal.
Clin Infect Dis, 48 (2009), pp. 101-107
[4.]
S. Lassalle, E. Selva, V. Hofman, et al.
Sarcoid-like lesions associated with the immune restoration inflammatory syndrome in AIDS: absence of polymerase chain reaction detection of Mycobacterium tuberculosis in granulomas isolated by laser capture microdissection.
Virchows Arch, 449 (2006), pp. 689-696
[5.]
M.A. French, P. Price, StoneF S.F..
Immune restoration disease after antiretroviral therapy.
AIDS, 18 (2004), pp. 1615-1627
[6.]
D.N. Amin, K. Sperber, L.K. Brown.
Positive Kveim test in patients with coexistingsarcoidosis and human immunodeficiency virus infection.
Chest, 101 (1992), pp. 1454-1456
[7.]
G. Foulon, M. Wislez, J.M. Naccache, et al.
Sarcoidosis in HIVinfected patients in the era of highly active antiretroviral therapy.
Clin Infect Dis., 38 (2004), pp. 418-425
[8.]
R.M. Viani.
Sarcoidosis and interstitial nephritis in a child with acquired immunodeficiency syndrome: implications of immune reconstitution syndrome with an indinavir-based regimen.
Pediatr Infect Dis J, 21 (2002), pp. 435-438
[9.]
J.M. Naccache, M. Antoine, M. Wislez, et al.
Sarcoid-like pulmonary disorder in human immunodeficiency virus-infected patients receiving antiretroviral therapy.
Am J Respir Crit Care Med., 159 (1999), pp. 2009-2013
[10.]
P. Blanche, B. Gombert, F. Rollot, D. Salmon, D. Sicard.
Sarcoidosis in a patient with acquired immunodeficiency syndrome treated with interleukin-2.
Clin Infect Dis, 31 (2000), pp. 1493-1494
[11.]
MorrisF D.G., R.M. Jasmer, L. Huang, M.B. Gotway, S. Nishimura, T.E. King Jr.
Sarcoidosis following HIV infection: evidence for CD4+ lymphocyte dependence.
Chest, 124 (2003), pp. 929-935
[12.]
M. Trevenzoli, A.M. Cattelan, F. Marino, U. Marchioro, P. Cadrobbi.
Sarcoidosis and HIV infection: a case report and a review of the literature.
Post Med J, 79 (2003), pp. 535-538
[13.]
R.A. Ferrand, J.D. Cartledge, J. Connolly, R.A. Standish, R.F. Miller.
Immune reconstitution sarcoidosis presenting with hypercalcaemia and renal failure in HIV infection.
Int J STD & AIDS, 18 (2007), pp. 138-139
[14.]
S.A. Shelburne 3rd, R.J. Hamill, M.C. Rodriguez-Barradas, et al.
Immune reconstitution inflammatory syndrome emergence of a unique syndrome during highly active antiretroviral therapy.
Medicine, 81 (2002), pp. 213-227
[15.]
R. Lenner, Z. Bregman, A.S. Teirstein, L. DePalo.
Recurrent pulmonary sarcoidosis in HIV-infected patients receiving highly active antiretroviral therapy.
Chest, 119 (2001), pp. 978-981
[16.]
L.B. Haramati, G. Lee, A. Singh, P.L. Molina, C.S. White.
Newly diagnosed pulmonary sarcoidosis in HIV-infected patients.
[17.]
V. Gomez, P.R. Smith, J. Burack, R. Daley, U. Rosa.
Sarcoidosis after antiretroviral therapy in a patient with acquired immunodeficiency syndrome.
Clin Infect Dis., 31 (2000), pp. 1278-1280
[18.]
P. Mirmirani, T.A. Maurer, B. Herndier, M. McGrath, M.D. Weinstein, T.G. Berger.
Sarcoidosis in a patient with AIDS: A manifestation of immune restoration syndrome.
J Am Acad Dermatol, 41 (1999), pp. 285-286
[19.]
P. Blanche, A. Passeron, B. Gombert, et al.
Sarcoidosis and HIV infection: influence of highly active antiretroviral therapy.
Br J Dermatol, 140 (1999), pp. 1185
[20.]
T. Korn, E. Bettelli, M. Oukka, V.K. Kuchroo.
IL-17 and Th17 Cells.
Ann Rev Immunol., 27 (2009), pp. 485-517
[21.]
B. Kanwar, D. Favre, J.M. McCune.
Th17 and regulatory T cells: implications for AIDS pathogenesis.
Curr Opin HIV AIDS, 5 (2010), pp. 151-157
[22.]
M.C. Iannuzzi, B.A. Rybicki, A.S. Teirstein.
Sarcoidosis.
N Engl J Med., 357 (2007), pp. 2153-2165
[23.]
M.W. Ziegenhagen, J. Müller-Quernheim.
The cytokine network in sarcoidosis and its clinical relevance.
J Intern Med., 253 (2003), pp. 18-30
[24.]
S.A. Klein, J.M. Dobmeyer, T.S. Dobmeyer, et al.
Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow Cytometry.
AIDS, 11 (1997), pp. 1111-1118
[25.]
I. Sereti, A.J. Rodger, M.A. French.
Biomarkers in immune reconstitution inflammatory syndrome: signals from pathogenesis.
Curr Opin HIV AIDS, 5 (2010), pp. 504-510
Copyright © 2011. Elsevier Editora Ltda.. All rights reserved
The Brazilian Journal of Infectious Diseases
Article options
Tools