Journal Information
Vol. 15. Issue 3.
Pages 249-252 (May - June 2011)
Share
Share
Download PDF
More article options
Vol. 15. Issue 3.
Pages 249-252 (May - June 2011)
Open Access
Physician adherence to guidelines for tuberculosis and HIV care in Rio de Janeiro, Brazil
Visits
2422
Valeria Saraceni1,
Corresponding author
valsaraceni@gmail.com

Rua Afonso Cavalcanti, 455 sala 809, Cidade Nova - Rio de Janeiro RJ - Brasil CEP 20211-901.
, Antonio Guilherme Pacheco2, Jonathan E. Golub3, Vitoria Vellozo4, Bonnie S. King5, Solange C. Cavalcante6, Lois Eldred7, Richard E. Chaisson8, Betina Durovni9
1 Technical Manager at SINAN, SMSDC-Rio de Janeiro, RJ, Brazil
2 Researcher PROCC, Fiocruz, Rio de Janeiro, RJ, Brazil
3 Center for Tuberculosis Research, Johns Hopkins University School of Medicine and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
4 Assistant, SIAP, SMSDCRio de Janeiro, RJ, Brazil
5 Center for Tuberculosis Research, Johns Hopkins University School of Medicine
6 Assistant, SIAP, SMSDCRio de Janeiro, RJ, Brazil
7 Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
8 Center for Tuberculosis Research, Johns Hopkins University School of Medicine and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
9 Superintendent, SIAP, SMSDC-Rio de Janeiro, RJ, Brazil
Ver más
This item has received

Under a Creative Commons license
Article information
Abstract
Background

Tuberculosis is the most common opportunistic infection among HIV-infected patients in Brazil. Brazil's national policy for HIV care recommends screening for latent tuberculosis (TB) and implementing isoniazid preventive therapy (IPT).

Objectives

We compared physician adherence to TB screening and other prevention and care policies among HIV primary care clinics in Rio de Janeiro City.

Methods

Data on performance of CD4 counts, viral load testing, tuberculin skin testing (TST) and IPT were abstracted from patient charts at 29 HIV clinics in Rio de Janeiro as part of the TB/HIV in Rio (THRio) study. Data on use of pneumocystis jiroveci pneumonia (PCP) prophylaxis were also abstracted from a convenience sample of 150 patient charts at 10 HIV clinics. Comparisons were made between rates of adherence to TB guidelines and other HIV care guidelines.

Results

Among the subset of 150 patients with confirmed HIV infection in 2003, 96% had at least one reported CD4 counts result; 93% had at least one viral load result reported; and, PCP prophylaxis was prescribed for 97% of patients with CD4 counts < 200 cells/mm3 or when clinically indicated. In contrast, 67 patients (45%) had a TST performed (all eligible); and only 11% (17) of eligible patients started IPT. Among 12,027 THRio cohort participants between 2003 and 2005, the mean number of CD4 counts and viral load counts was 2.5 and 1.9, respectively, per patient per year. In contrast, 49% of 8,703 eligible patients in THRio had a TST ever performed and only 53% of eligible patients started IPT.

Conclusion

Physicians are substantially more compliant with HIV monitoring and PCP prophylaxis than with TB prophylaxis guidelines. Efforts to improve TB control in HIV patients are badly needed.

Keywords:
AIDS-related opportunistic infections
tuberculosis
disease prevention
guideline adherence
Full text is only aviable in PDF
References
[1.]
L.F. Jamal, F. Moherdaui.
Tuberculosis and HIV infection in Brazil: magnitude of the problem and strategies for control.
Rev Saúde Pública, 41 (2007), pp. 104-110
[2.]
A.G. Pacheco, B. Durovni, S.C. Cavalcante, et al.
AIDS-related tuberculosis in Rio de Janeiro.
Brazil. PLoS ONE, 3 (2008), pp. e31-e32
[3.]
V. Saraceni, B.S. King, J.E. Golub, L.M. Lauria, S.C. Cavalcante, B. Durovni.
Tuberculosis as primary cause of death among AIDS cases in Rio de Janeiro City.
Brazil. Int J Tuberc Lung Dis, 12 (2008), pp. 769-772
[4.]
Secretaria Municipal de Saúde do Rio de Janeiro. Gerência do Programa de DST/AIDS. Rio de Janeiro; 2008. Accessed from.http://www.saude.rio.rj.gov.br/aids/.
[5.]
Brazil. Ministry of Health. Recommendations on Antiretroviral Therapy in HIV-infected Adults and Adolescents. Brasilia; 2008.
[6.]
C. Brand, F. Landgren, A. Hutchinson, C. Jones, L. Macgregor, D. Campbell.
Clinical practice guidelines: barriers to durability after effective early implementation.
Intern Med J, 35 (2005), pp. 162-169
[7.]
M.D. Cabana, C.S. Rand, N.R. Powe, et al.
Why don’t physicians follow clinical practice guidelines? A framework for improvement.
JAMA, 282 (1999), pp. 1458-1465
[8.]
Centers for Disease Control and Prevention (CDC). Current Trends Prevention of Acquired Immune Deficiency Syndrome (AIDS): Report of Inter-Agency Recommendations. MMWR 1983; 32:101-3.
[9.]
M.I. Nemes, H.B. Carvalho, M.F. Souza.
Antiretroviral therapy adherence in Brazil.
AIDS, 18 (2004), pp. S15-S20
[10.]
L. Moulton, J.E. Golub, B. Durovni, et al.
Statistical design of THRio: a phased implementation clinic-randomized study of a tuberculosis preventive therapy intervention.
Clin Trials, 4 (2007), pp. 190-199
[11.]
Secretaria Municipal de Saúde do Rio de Janeiro. Gerência do Programa de Pneumologia Sanitária. Rio de Janeiro; 2008. Accessed from.http://www.saude.rio.rj.gov.br/tuberculose/.
[12.]
J. Sackoff, J. McFarland, S. Su, E. Bryan.
Prophylaxis for opportunistic infections among HIV-infected patients receiving medical care.
J Acquir Immune Defic Syndr Hum Retrovirol, 19 (1998), pp. 387-392
[13.]
J.S. Montaner, P. Phillips, C. Zala, K.J. Craib, M.V. O'Shaughnessy, M.T. Schechter.
Adherence to guidelines for the prevention of HIV-related respiratory diseases.
Eur Respir J, 9 (1996), pp. 2318-2322
[14.]
J.E. Golub, V. Saraceni, S.C. Cavalcante, et al.
The impact of antiretroviral therapy and isoniazid preventive therapy on tuberculosis incidence in HIV-infected patients in Rio de Janeiro.
Brazil. AIDS, 21 (2007), pp. 1441-1448
[15.]
J.E. Sackoff, L.V. Torian, T.R. Frieden, K.F. Brudney, I.B. Menzies.
Purified protein derivative testing and tuberculosis preventive therapy for HIV-infected patients in New York City.
AIDS, 12 (1998), pp. 2017-2023
[16.]
L.M. Lee, M.N. Lobato, S.E. Buskin, A. Morse, S. Costa.
Low adherence to guidelines for preventing TB among persons with newly diagnosed HIV infection.
United States. Int J Tuberc Lung Dis, 10 (2006), pp. 209-214
[17.]
G. Antonucci, E. Girardi, M. Raviglione, et al.
Guidelines of tuberculosis preventive therapy for HIV-infected persons: a prospective, multicentre study.
Eur Respir J, 18 (2001), pp. 369-375
[18.]
K. De Riemer, C.L. Daley, A.L. Reingold.
Preventing tuberculosis among HIV-infected patients: a survey of physicians’ knowledge and practices.
Prev Med, 28 (1999), pp. 437-441
[19.]
N. Hiransuthikul, P. Hiransuthikul, K.E. Nelson, M. Jirawisit, R. Paewplot, S. Kasak.
Physician adherence to isoniazid preventive therapy guidelines for HIV-infected patients in Thailand.
Southeast Asian J Trop Med Public Health, 36 (2005), pp. 1208-1215
[20.]
V. Vellozo, G. Israel, V. Saraceni, R.C.M. Ferreira, B. Durovni, A. DeLuca.
THRio qualitative study (Abstract PS-82357-20). In: Program and abstracts.
38th Union World Conference on Lung Health Paris,
[21.]
G.J. Churchyard, F. Scano, A.D. Grant, R.E. Chaisson.
Tuberculosis preventive therapy in the era of HIV infection: overview and research priorities.
J Infect Dis, 196 (2007), pp. S52-S62
[22.]
D.E. Snider Jr., G.J. Caras.
Isoniazid-associated hepatitis deaths: a review of available information.
Am Rev Respir Dis, 145 (1992), pp. 494-497
[23.]
WHO. WHO Three I's Meeting: Report of a Joint WHO HIV/AIDS and TB Department Meeting. Geneva, Switzerland: WHO, 2008.
Copyright © 2011. Elsevier Editora Ltda.. All rights reserved
The Brazilian Journal of Infectious Diseases
Article options
Tools