Article information
Abstract
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.
Keywords:
malaria
Plasmodium vivax
treatment
primaquine
hemolysis
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References
[1.]
Brazilian Ministry of Health. Epidemiology of Malaria in Brazil, 2007. Available at: http://portal.saude.gov.br/portal/arquivos/pdf/folder_malaria_2008_final.pdf. Accessed 17 November 2009.
[2.]
W.A. Krotoski.
The hypnozoite and malarial relapse.
Prog Clin Parasitol, 1 (1989), pp. 1-19
[3.]
Brazilian Ministry of Health. Brazilian Antimalarial Therapy Guideline. Available at: http://portal.saude.gov.br/portal/arquivos/pdf/manu_terapeutica_malaria.pdf. Accessed 19 March 2009.
[4.]
S. Krudsood, N. Tangpukdee, P. Wilairatana, et al.
High-dose primaquine regimens against relapse of Plasmodium vivax malaria.
Am J Trop Med Hyg, 78 (2008), pp. 736-740
[5.]
J.K. Baird, S.L. Hoffman.
Primaquine therapy for malaria.
Clin Infect Dis, 39 (2004), pp. 1336-1345
[6.]
World Health Organization.
Glucose-6-phosphate dehydrogenase deficiency.
Bull World Health Organ, 67 (1989), pp. 601-611
[7.]
E. Beutler, S. Duparc.
Glucose-6-phosphate dehydrogenase deficiency and antimalarial drug development.
Am J Trop Med Hyg, 77 (2007), pp. 779-789
[8.]
M.S. Santana, M.A. Rocha, A.R. Arcanjo, et al.
Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine.
Rev Soc Bras Med Trop, 40 (2007), pp. 533-536
[9.]
G.J. Brewer, A.R. Tarlov, A.S. Alving.
The methemoglobin reduction test for primaquine-type sensitivity of erythrocytes. A simplified procedure for detecting a specific hypersusceptibility to drug hemolysis.
JAMA, 180 (1962), pp. 386-388
[10.]
M.C. Silva, E.B. Santos, E.G. Costal, et al.
Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6 -phosphate dehydrogenase deficiency treated with primaquine at 0.50 mg/kg/day.
Rev Soc Bras Med Trop, 37 (2004), pp. 215-217
[11.]
M.E. Carr Jr., M.N. Fandre, F.O. Oduwa.
Glucose-6-phosphate dehydrogenase deficiency in two returning Operation Iraqi Freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria.
Mil Med, 170 (2005), pp. 273-276
[12.]
V. Sakhuja, K. Sud.
Acute renal failure in the tropics.
Saudi J Kidney Dis Transplant, 4 (1999), pp. 247-260
[13.]
M.S. Santana, M.V.G. Lacerda, M.G.V. Barbosa, et al.
Glucose-6- phosphate dehydrogenase deficiency in an endemic area for malaria in Manaus: a cross-sectional survey in the Brazilian Amazon.
PLoS ONE, 4 (2009), pp. e5259
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