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Vol. 14. Issue 5.
Pages 449-456 (September - October 2010)
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Vol. 14. Issue 5.
Pages 449-456 (September - October 2010)
Original article
Open Access
DMFT index and oral mucosal lesions associated with HIV infection: cross-sectional study in Porto Velho, Amazonian Region - Brazil
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Rodrigo Queiroz Aleixo1,
Corresponding author
rodrigoaleixo@yahoo.com.br

Correspondence to: Rua Beethoven, 4604 - Nova Esperança Porto Velho – RO – Brazil CEP: 76822-200 Phone: +55-69-92316955.
, Alexandre Prado Scherma2, Gustav Guimarães1, José Roberto Cortelli3, Sheila Cavalca Cortelli3
1 Master's Degree in Dentistry, Unitau – Professor of Faculdade São Lucas
2 Post-Graduation in Dentistry – Assistant Professor of Instituto Básico de Biociências, Unitau
3 Post-Graduation in Dentistry – Assistant Professor of Preventive Dentistry and Cariology, and Periodontoly, Unitau
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Abstract

We evaluated the DMFT (decayed, missing and filled teeth) index and the prevalence of candidiasis, linear gingival erythema, oral hairy leukoplakia, herpes simplex, aphthous ulcers, Kaposi's sarcoma and lymphoma, as well as the association with TCD4 count, viral load (VL) and antiretroviral therapy (ART) in 140 HIV-infected adult individuals. A standardized examination to determine the DMFT index and the presence of oral lesions was conducted. Demographic data, TCD4 count and use of ART were obtained from medical records. A high number of decayed teeth detected among patients undergoing ART resulted in a mean DMFT of 16.9 teeth. It was observed that 24.2% of the individuals had at least one oral lesion. Candidiasis was the most frequent lesion and was associated with the TCD4 count. Oral hairy leukoplakia was associated with an increased VL. Regular use of ART was inversely associated with the occurrence of lesions. Overall, the studied population showed low prevalence of oral lesions and high DMFT index. The use of ART seems to reduce the occurrence of these lesions. Higher TCD4 count and a lower VL were associated with an improved oral health status in HIV+ individuals.

Keywords:
oral mucosal lesions
DMFT index
tooth decay
HIV infection
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References
[1.]
Brasil Ministério da Saúde. Secretaria de Vigilância em Saúde. Programa Nacional de DST E AIDS. Boletim Epidemiológico Aids e DST 2007; IV(1):48 [cited 2008 Apr 19]. Available from http://www.aids.gov.br.
[2.]
C. Mims, H.M. Dockrell, R.V. Goering, et al.
Microbiologia médica.
Rio de Janeiro: Elsevier, (2005), pp. 284-295
[3.]
D.S. Lewi, G. Turcato Jr, A. Castelo Filho, R.S. Diaz.
Síndrome da Imunodeficiência Adquirida (Aids).
Guias de medicina ambulatorial e hospitalar-Infectologia Unifesp/Escola Paulista de Medicina, pp. 125-134
[4.]
A.R. Marques, H. Masur.
História natural da infecção pelo HIV.
Veronesi: tratado de infectologia, 3ª edição, pp. 143-147
[5.]
R.I. Ferreira, A.A.P. Valença Neto, D.C. Vianna, et al.
Estudo da prevalência de alterações bucais em pacientes HIV+ do Hospital Universitário Prof. Edgard Santos – Salvador, BA.
Rev Fac Odontol Univ Fed Bahia, 18 (1999), pp. 22-27
[6.]
M.R. Volkweis, R.S.da Rocha, L.L.N. Leonardo, J.C.B. Wagner.
Lesões bucais manifestadas em pacientes aidéticos e tuberculosos, relacionadas com a contagem celular cd4+/cd8+.
PGR-Pós-Grad Rev Fac Odontol São José dos Campos, 4 (2001), pp. 74-82
[7.]
S.M.L. Fabro, I.B.S. Rath, L.J. Grando, et al.
Estudo das manifestações estomatológicas em pacientes infectados pelo HIV, atendidos no Hospital Nereu Ramos – Florianópolis – SC, Brasil.
RPG Rev Pos Grad, 9 (2002), pp. 12-19
[8.]
S. Silverman Jr, M. Glick.
Doenças associadas com o vírus da Imunodeficiência Humana.
Fundamentos de Medicina Oral, pp. 128-143
[9.]
C.W. Noce, R.S. Pinheiro, A.C.B. Souza, et al.
Prevalência de lesões orais na infecção por HIV em adultos e crianças.
Rev Bras Odontol, 63 (2006), pp. 126-129
[10.]
G.F. Castro, I.P.R. Souza, R.H.S. Oliveira, et al.
Prevalência de cárie e sua correlação com a classificação clínica e imunológica em crianças infectadas pelo HIV.
Pesqui Odontol Bras, 15 (2001), pp. 91-97
[11.]
L.B. Souza, L. Pereira Pinto, A.M.C. Medeiros, et al.
Manifestações orais em pacientes com Aids em uma população brasileira.
Pesqui Odontol Bras, 14 (2000), pp. 79-85
[12.]
J.A. Phelan, R. Mulligan, E. Nelson, et al.
Dental caries in HIV-seropositive women.
J Dent Res, 83 (2004), pp. 869-873
[13.]
L. Patton, D.C. Shugars.
Immunologic and viral markers of HIV-1 disease progression: implications for dentistry.
JADA, 130 (1999), pp. 1313-1322
[14.]
Brasil Ministério da Saúde. Secretaria de vigilância em saúde. Programa Nacional de DST e Aids. Recomendações para terapia antiretroviral em adultos e adolescentes infectados pelo HIV: 2005/2006. 6th ed. Brasília: Ministério da Saúde, 2007.
[15.]
World Health Organization. Assessment Forms. In: Oral Health Surveys Basic Methods. 4th ed. Geneva, 1997. p. 21-50.
[16.]
Brasil Ministério da Saúde. Projeto SB Brasil – Condições de saúde bucal da população brasileira. Manual do Examinador. Brasília: Ministério da Saúde, 2001.
[17.]
L.J. Grando, L.S. Yurgel, D.C. Machado, et al.
Manifestações estomatológicas, contagem de linfócitos T-CD4+ e carga viral de crianças brasileiras e norte-americanas infectadas pelo HIV.
Pesqui Odontol Bras, 16 (2002), pp. 18-25
[18.]
Brasil Ministério da Saúde. Secretaria de Vigilância em Saúde. Programa Nacional de DST e AIDS. Boletim Epidemiológico Aids e DST 2005; II(1):42 [cited 2008 Apr 19]. Available from http://www.aids.gov.br.
[19.]
D.M. Stoff, J.H. Khalsa, A. Monjan, P. Portegies.
Introduction: HIV/AIDS and Aging.
AIDS, 18 (2004), pp. S1-S2
[20.]
M.G.P. Fonseca, F.I. Bastos.
Twenty-five years of the AIDS epidemic in Brazil: principal epidemiological findings, 1980–2005. Cad.
Saúde Pública, 23 (2007), pp. S333-S344
[21.]
B.G.A. Souto.
HIV/AIDS in the small cities: a Brazilian epidemiology study.
Rev. Cubana Med Trop, 56 (2004), pp. 91-93
[22.]
C.W. Noce, A. Silva Júnior, S.M.S. Ferreira.
Panorama mundial da epidemia pelo HIV/Aids: Aspectos sociais e lesões bucais.
DST – J Bras Doenças Sex Transm, 17 (2005), pp. 301-305
[23.]
S.M. Hammer, D.A. Katzenstein, M.D. Hughes, et al.
A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter.
N Engl J Med, 335 (1996), pp. 1081-1090
[24.]
W. Birnbaum, T.A. Hodgson, P.A. Reichart, et al.
Prognostic significance of HIV-associated oral lesions and their relation to therapy.
Oral Diseases, 8 (2002), pp. 110-114
[25.]
D. Greenspan, A.J. Canchola, L.A. MacPhail, B. Cheikh, J.S. Greenspan.
Effect of highly active antiretroviral therapy on frequency of oral warts.
Lancet, 357 (2001), pp. 1411-1412
[26.]
I. Greenwood, J.M. Zakrzewska, P.G. Robinson.
Changes in the prevalence of HIV-associated mucosal disease at a dedicated clinic over 7 years.
Oral Diseases, 8 (2002), pp. 90-94
[27.]
M.T.S. Barbosa, C.J. Struchiner.
Impacto da terapia antirretroviral na magnitude da epidemia do HIV-Aids no Brasil: diversos cenários.
Cad Saúde Pública, 19 (2003), pp. 535-541
[28.]
S.L. Mattos, V.R. Santos, E.F. Ferreira.
Prevalência das lesões de mucosa bucal em pacientes HIV-positivos da unidade de referência especializada em doenças infecciosas e parasitárias especiais – URE-DIPE (Belém-Pará).
Rev Bras Patol Oral, 3 (2004), pp. 7-16
[29.]
K. Ranganathan, R. Hemelatha.
Oral lesion in HIV infection in developing countries: an overview.
Adv Dent Res, 19 (2006), pp. 63-68
[30.]
K. Ranganathan, M. Umadevi, T.R. Saraswathi, N. Kumarasamy, S. Solomon, N. Johnson.
Oral lesions and conditions associated with human immunodeficiency virus infection in 1000 South-Indian patients.
Ann Acad Med Singapore, 33 (2004), pp. 37-42
[31.]
S. Ferreira, C.W. Noce, A. Silva Jr, et al.
Prevalence of Oral Manifestations of HIV Infection in Rio de Janeiro, Brazil from 1988 to 2004.
Aids Patient Care and STDs, 21 (2007), pp. 724-731
[32.]
F.M. Silveira, M. Rangel.
Perfil Biopsicossocial de pacientes do programa de atenção à saúde bucal.
Pesq Bras Odontoped Clín Integr, 4 (2004), pp. 221-226
[33.]
O.J.M. Hamza, M.I.N. Matee, E.N.M. Simon, et al.
Oral manifestations of HIV infection in children and adults receiving highly active antiretroviral therapy [HAART] In: Dar Es Salaam, Tanzania.
BMC Oral Health, 6 (2006), pp. 1-9
[34.]
S.A. Pithan, L.R. Schardosim, M.A.Z. Figueiredo.
Manejo clínico da leucoplasia oral.
Rev Bras Patol Oral, 2 (2003), pp. 40-45
[35.]
I.D. Miziara, A.S. Lima, R.A.C. Cortina.
Candidíase oral e leucoplasia pilosa como marcadores de progressão da infecção pelo HIV em pacientes brasileiros.
Rev Bras Otorrinolaringol, 70 (2004), pp. 310-314
[36.]
L.L. Patton, R.G. McKaig, J.J. Eron, H.P. Lawrencw, R.P. Strauss.
Oral hairy leukoplakia and oral candidiasis as predictors of HIV viral load.
AIDS, 13 (1999), pp. 2174-2176
[37.]
G.C. Girotto, M. Coutinho Neto, N.L.M. Moreira, et al.
Sarcoma de Kaposi: novas perspectivas.
J Bras Med, 87 (2004), pp. 59-70
[38.]
T.M.S. Candiani, J. Pinto, C.A.A. Cardoso, et al.
Impact of highly active antiretroviral therapy (HAART) on the incidence of opportunistic infections, hospitalizations and mortality among children and adolescents living with HIV/AIDS in Belo Horizonte, Minas Gerais State, Brazil.
Cad Saúde Pública, 23 (2007), pp. S414-S423
[39.]
M.M. Coogan, J. Greenspan, S.J. Challacombe.
Oral lesions in infection with human immunodeficiency virus.
Bull World Health Organ, 83 (2005), pp. 700-706
[40.]
D. Greenspan, S.J. Gange, J.A. Phelan, et al.
Incidence of Oral Lesions in HIV-1-infected Women: Reduction with HAART.
J Dent Res, 83 (2004), pp. 145-150
[41.]
W.A. Bretz, C. Flaitz, A. Moretti, et al.
Medication usage and dental caries outcome-related variables in HIV/AIDS patients.
Aids patient care and STDs, 14 (2000), pp. 549-554
[42.]
Organização Mundial da Saúde. Organização Pan-Americana da Saúde (OPAS/OMS) – Brasil. Saúde Bucal [cited 2008 May 1st]. Available from http://www.opas.org.br/sistema/fotos/bucal.pdf.
[43.]
Brasil Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Projeto SB Brasil 2003: condições de saúde bucal da população brasileira 2002-2003: resultados principais. Brasília: Ministério da Saúde, 2004.
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The Brazilian Journal of Infectious Diseases
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