TY - JOUR T1 - Low frequency of hypersensitivity reactions to abacavir in HIV infected patients in a referral center in Bahia, Brazil JO - The Brazilian Journal of Infectious Diseases T2 - AU - Barreto,Raphael Gusmão AU - Brites,Carlos SN - 14138670 M3 - 10.1016/j.bjid.2019.06.003 DO - 10.1016/j.bjid.2019.06.003 UR - https://www.bjid.org.br/en-low-frequency-hypersensitivity-reactions-abacavir-articulo-S1413867019300613 AB - Abacavir can cause a multi-systemic hypersensitivity reaction (HSR) in 5–8% of the patients, which is related to HLA-B*57-01 allele. In Brazil, the HLA-B*57-01 screening test became available only in March 2018, several years after abacavir was in use. In this retrospective study we reviewed medical charts of all patients receiving an abacavir-containing regimen to evaluate the frequency of HSR in patients followed at a referral center in Salvador, Brazil. A total of 192 patients who received abacavir were identified, most male (67.1%), black or racially mixed (77.8%), and having diagnosis of a previous AIDS defining conditions (83.7%). Only one patient developed HSR (incidence: 0.52%). The main reasons for abacavir-containing antiretroviral therapy discontinuation were virological failure (28%), adverse effects to other components of the regimen (25%), and simplification of therapy (16%). The low incidence of HSR to abacavir does not support the use of HLA-B*57-01 screening test, in Salvador, Brazil. ER -