TY - JOUR T1 - Unusual oral findings of the toxic epidermal necrolysis in an HIV-infected patient: a case report JO - The Brazilian Journal of Infectious Diseases T2 - AU - da Costa Vieira,Vinicius AU - Almeida Sarmento,Viviane AU - Leite Ribeiro,Patricia Miranda AU - Martins Netto,Eduardo AU - Brites,Carlos AU - Lins-Kusterer,Liliane SN - 14138670 M3 - 10.1016/j.bjid.2019.08.003 DO - 10.1016/j.bjid.2019.08.003 UR - https://www.bjid.org.br/en-unusual-oral-findings-toxic-epidermal-articulo-S1413867019304210 AB - Erythema multiforme (EM), Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (TEN) have been reported as possible adverse effects of some classes of first-line antiretroviral drugs (ART) for HIV treatment. Herein we report an unusual presentation of TEN lesions associated with ART in an HIV-infected patient. The patient presented disseminated cutaneous eruption and oral lesions from the lips to the oropharynx region, causing odynophagia and dysphagia. In the tongue, circular, atypical erythematous lesions appeared, increasing in diameter over seven days and coalescing since then to complete remission. TEN treatment included efavirenz interruption, use of methylprednisolone, prophylactic antibiotic, and daily laser therapy with low-intensity red light. The circular oral lesions have not been described yet. Reporting our findings and clinical management may help diagnosing other similar cases and guide the clinical conduct. Analgesia and acceleration of oral ulcer repair with red laser therapy are recommended. ER -