TY - JOUR T1 - Sustained reduction of healthcare-associated infections after the introduction of a bundle for prevention of ventilator-associated pneumonia in medical-surgical intensive care units JO - The Brazilian Journal of Infectious Diseases T2 - AU - Fortaleza,Carlos Magno Castelo Branco AU - Filho,SebastiĆ£o Pires Ferreira AU - Silva,Marina de Oliveira AU - Queiroz,Sandra Mara AU - Cavalcante,Ricardo de Souza SN - 14138670 M3 - 10.1016/j.bjid.2020.08.004 DO - 10.1016/j.bjid.2020.08.004 UR - https://www.bjid.org.br/en-sustained-reduction-healthcare-associated-infections-after-articulo-S1413867020301197 AB - BackgroundInfection control interventions can be erroneously interpreted if outcomes are assessed in short periods. Also, statistical methods usually applied to compare outcomes before and after interventions are not appropriate for analyzing time series. AimsTo analyze the impact of a bundle directed at reducing the incidence of ventilator-associated pneumonia (VAP) and other device-associated infections in two medical-surgical intensive care units (ICU) in Brazil. MethodsOur study had a quasi-experimental design. Interrupted time series analyses (ITS) was performed assessing monthly rates of overall healthcare-associated infections (HCAI), VAP, laboratory-confirmed central line associated bloodstream infections (CLABSI) and catheter-associated urinary tract infections (CAUTI), from January 2007 through June 2019. Moreover, multivariate ITS was adjusted for seasonality in Poisson regression models. An intervention based on a bundle for VAP prevention was introduced in August 2010. FindingsThe intervention was followed by sustained reduction in overall HCAI, VAP and CLABSI in both ICU. Continuous post-intervention trends towards reduction were detected for overall HCAI and VAP. ConclusionInterventions aimed at preventing one specific site of infection may have sustained impact on other HCAI, which can be documented using time series analyses. ER -