TY - JOUR T1 - Is it cost effective to use a 2% chlorhexidine wipes bath to reduce central-line associated blood stream infection? A quasi-experimental study JO - The Brazilian Journal of Infectious Diseases T2 - AU - Feriani,Diego AU - Souza,Ercilia Evangelista AU - Carvalho,Larissa Gordilho Mutti AU - Ibanes,Aline Santos AU - Vasconcelos,Eliana AU - Barbosa,Vera Lucia AU - Kondo,Sandra Kiyomi AU - Abboud,Cely S. SN - 14138670 M3 - 10.1016/j.bjid.2021.101538 DO - 10.1016/j.bjid.2021.101538 UR - https://www.bjid.org.br/en-is-it-cost-effective-use-articulo-S1413867021000015 AB - BackgroundBathing with 2% chlorhexidine (CHG) wipes is an important measure regarding infection prevention in critically ill patients. The aim of this study was to evaluate the impact of CHG wipes bath to prevent central-line associated bloodstream infection (CLABSI) in critically ill patients and determine if such measure is cost-saving. Methodsa quasi-experimental study, conducted from July 2017 to April 2019. Daily bath with 2% CHG was used in all patients at the unit in the intervention period. The following were evaluated: CLABSI incidence density in both periods, 30- day mortality, guided antimicrobials used to treat CLABSI and 2% CHG costs. ResultsCLABSI incidence density dropped from 8.69 to 1.83 per 1.000 central line-days (p = 0.001), mainly by Klebsiella pneumoniae Carbapenen Resistant (Kp-KPC) (p = 0.05). Costs with guided antimicrobials for the treatment in pre-intervention were US$ 46,114.36, and in the intervention period, US$ 4,177.50. The 2% CHG monthly cost was US$ 2,698.00, achieving 30% savings when comparing both periods. DiscussionAn expressive reduction of 79% in CLABSI incidence density was observed, mainly due to Kp-KPC infection and also a reduction in guided antimicrobial costs. ConclusionsBathing with 2% CHG led to evident CLABSI reduction. ER -