Prevalence of toxoplasmosis, HIV, syphilis and rubella in a population of puerperal women using Whatman 903® filter paper

Madi, José Mauro; de Souza, Ricardo da Silva; de Araújo, Breno Fauth; de Oliveira Filho, Petrônio Fagundes; Rombaldi, Renato Luís; Mitchell, Charles; Lorencetti, Jucemara; Marcon, Nathalia Oliva

doi:10.1016/S1413-8670(10)70006-4

The Brazilian Journal of Infectious Diseases

ISSN: 1413-8670

The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents.
The BJID is a bimonthly publication and one of the most influential journals in its field in Brazil and Latin America with a high impact factor. Since its inception it has garnered a growing share of the publishing market.

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A prospective, cross-sectional study was performed from February 2007 to April 2008 at Hospital Geral, Universidade de Caxias do Sul in a population of 1,510 puerperal women. Women that gave birth to live born or stillborn infants were included in the study; maternal and perinatal variables were analyzed. Descriptive statistics and Pearson's chi-square with occasional Fisher's correction were used for comparisons. Alpha was set in 5%.

Results

A total of 148 cases of congenital infection (9.8%) were identified: 66 cases of syphilis (4.4%), 40 cases of HIV (2.7%), 27 cases of toxoplasmosis (1.8%) and 15 cases of rubella (1.0%). In ten cases there was co-infection (four cases of HIV and syphilis, two cases of HIV and rubella, one case of HIV and toxoplasmosis, two cases of rubella and syphilis, and one case of toxoplasmosis and rubella). In a comparison between puerperal women with and without infection there was no statistical significance in relation to incidence of abortions, small for gestational age, prematurity, live births and stillbirths, and prenatal care. Need of neonatal intensive care unit (NICU), maternal schooling, maternal age higher than 35 years and drug use (alcohol, cocaine and crack) had statistical significance.

Conclusion

The prevalence rate of infections was 9.8%. Need of NICU, maternal schooling lower than eight years, maternal age higher than 35 years and drug use were significantly associated with occurrence of congenital infection.

Keywords:

perinatal infections

congenital infections

clinical diagnosis

seroprevalence

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References

[1.]

P.J. Wendel, G.D. Wendel Jr..

Sexually transmitted diseases in pregnancy.

Sem Perinatol, 17 (1993), pp. 443-451

[2.]

J.M. Forrest, F.M. Turnbull, G.F. Sholler, et al.

Gregg's congenital rubella patients 60 years later.

Med J Australia, 177 (2002), pp. 664-667

Medline

[3.]

D.R.S. Lorenzi, J.M. Madi.

Sífilis congênita como indicador de assistência pré-natal.

Rev Bras Ginecol Obstet, 23 (2001), pp. 647-652

[4.]

A.N. Ramos Jr, L.H. Matida, V. Saraceni, et al.

Control of motherto-child transmission of infectious diseases in Brazil: progress in HIV/AIDS and failure in congenital syphilis.

Cad Saude Pub, 23 (2007), pp. S370-S378

[5.]

M. Fontes, J. Hillis, G. Wasek.

Children affected by AIDS in Brazil: estimates of the number of children at risk of being orphaned and displaced by AIDS in Brazil.

Childhood, 5 (1998), pp. 345-363

[6.]

E.M. Connor, R.S. Sperling, R. Gelber, et al.

Reduction of maternalinfant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.

NEJM, 331 (1994), pp. 1173-1180

http://dx.doi.org/10.1056/NEJM199411033311801 | Medline

[7.]

M.Z. Goldani, E.R. Giugliani, T. Scanlon, et al.

Voluntary HIV counseling and testing during prenatal care in Brazil.

Rev Saude Pub, 37 (2003), pp. 552-558

[8.]

H.M. Elsheikha.

Congenital toxoplasmosis: priorities for further health promotion action.

Public Health, 122 (2008), pp. 335-353

http://dx.doi.org/10.1016/j.puhe.2007.08.009 | Medline

[9.]

M. De Paschale, C. Agrappi, P. Clerici, et al.

Seroprevalence and incidence of Toxoplasma gondii infection in the Legnano area of Italy.

Clin Microbiol Infect, 14 (2008), pp. 186-189

http://dx.doi.org/10.1111/j.1469-0691.2007.01883.x | Medline

[10.]

A.C. Kimball, B.H. Kean, F. Fuchs.

Congenital toxoplasmosis: a prospective study of 4,048 obstetric patients.

Am J Obstet Gynecol, 111 (1971), pp. 211-218

Medline

[11.]

W. Ferguson, P.D. Mayne, B. Lennon, et al.

Susceptibility of pregnant women to toxoplasma infection:--potential benefits for newborn screening.

Irish Med J, 101 (2008), pp. 220-221

[12.]

J.L. Jones, D. Kruszon-Moran, M. Wilson, et al.

Toxoplasma gondii infection in the United States: seroprevalence and risk factors.

Am J Epidemiol, 154 (2001), pp. 357-365

Medline

[13.]

C.A. Alford Jr., S. Stagno, D.W. Reynolds.

Congenital toxoplasmosis: clinical, laboratory, and therapeutic considerations, with special reference to subclinical disease.

Bull New York Acad Med, 50 (1974), pp. 160-181

[14.]

N.G. Guerina, H.W. Hsu, H.C. Meissner, et al.

Neonatal serologic screening and early treatment for congenital Toxoplasma gondii infection. The New England Regional Toxoplasma Working Group.

NEJM, 330 (1994), pp. 1858-1863

http://dx.doi.org/10.1056/NEJM199406303302604 | Medline

[15.]

M. Vela-Amieva, I. Canedo-Solares, P. Gutierrez-Castrellon, et al.

Short report: neonatal screening pilot study of Toxoplasma gondii congenital infection in Mexico.

Am J Trop Med Hyg, 72 (2005), pp. 142-144

Medline

[16.]

E. Figueiró Filho, F. Senefonte, A. Lopes, et al.

Frequência das infecções pelo HIV-1, rubéola, sífilis, toxoplasmose, citomegalovírus, herpes simples, hepatite B, hepatite C, doença de Chagas e HTLV I/II em gestantes do Estado de Mato Grosso do Sul.

Rev Soc Bras Med Trop, 40 (2007), pp. 181-187

Medline

[17.]

E. Figueiró-Filho, A. Lopes, F. Senefonte, et al.

Toxoplasmose aguda: estudo da frequência, taxa de transmissão vertical e relação entre os testes diagnósticos materno-fetais em gestantes em estado da Região Centro-Oeste do Brasil.

Rev Bras Ginecol Obstet, 27 (2005), pp. 442-449

[18.]

A. Porto, M. Amorim, I. Coelho, L. Santos.

Serologic profile of toxoplasmosis in pregnant women attended at a teaching-hospital in Recife.

Rev Assoc Med Bras, 54 (2008), pp. 242-248

Medline

[19.]

F. Rosso, J.T. Les, A. Agudelo, et al.

Prevalence of infection with Toxoplasma gondii among pregnant women in Cali, Colombia, South America.

Am J Trop Med Hyg, 78 (2008), pp. 504-508

Medline

[20.]

E. Miller, J.E. Cradock-Watson, T.M. Pollock.

Consequences of confirmed maternal rubella at successive stages of pregnancy.

Lancet, 2 (1982), pp. 781-784

http://dx.doi.org/10.1016/S2213-2600(14)70183-3 | Medline

[21.]

CDC. Achievements in Public Health: Elimination of Rubella and Congenital Rubella Syndrome- United States, 1969-2004.

JAMA, 293 (2005), pp. 2084-2086

[22.]

Control and prevention of rubella: evaluation and management of suspected outbreaks, rubella in pregnant women, surveillance for congenital rubella syndrome.

MMWR Recomm Rep, 50 (2001), pp. 1-23

Medline

[23.]

Elimination of rubella and congenital rubella syndrome - United States, 1969-2004.

MMWR, 54 (2005), pp. 279-282

Medline

[24.]

T.M. Lanzieri, T.C. Segatto, M.M. Siqueira, et al.

Burden of congenital rubella syndrome after a community-wide rubella outbreak, Rio Branco, Acre, Brazil, 2000 to 2001.

Ped Infec Dis J, 22 (2003), pp. 323-329

[25.]

E.M. Reiche, H.K. Morimoto, G.N. Farias, et al.

Prevalence of American trypanosomiasis, syphilis, toxoplasmosis, rubella, hepatitis B, hepatitis C, human immunodeficiency virus infection, assayed through serological tests among pregnant patients, from 1996 to 1998, at the Regional University Hospital Norte do Parana.

Rev Soc Bras Med Trop, 33 (2000), pp. 519-527

Medline

☆

This study was approved by the Research Ethics Committee of Hospital Geral and Universidade de Caxias do Sul, and there are no restrictions for publication.

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