Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1865, Issue 4, 1 April 2019, Pages 759-773
ReviewThe role of mitochondria in sepsis-induced cardiomyopathy☆
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Abbreviations
LPS
lipopolysaccharide
CASP
colon ascendens stent peritonitis
CLP
cecal ligation and puncture (CLP)
cNOS
constitutive nitric oxide synthase
CO
carbon monoxide
DAMPs
danger-associated molecular patterns
Drp1
dynamin-related protein 1
iNOS
inducible nitric oxide synthase
Mfns
mitofusins
mPTP
mitochondrial permeability transition pore
mtNOS
mitochondrial NOS
NO
nitric oxide
NRF-1 and -2
nuclear respiratory factors 1 and 2
PAMPs
pathogen-associated molecular patterns
OPA1
optic atrophy 1
PARP
poly(ADP-ribose) polymerase
PGC-1α and β
PPAR (peroxisome proliferator-activated receptor)-γ coactivator-1 α and β
PPAR
peroxisomal proliferator-activated receptors
RNS
reactive nitrogen species
ROS
reactive oxygen species
RyR
ryanodine receptor
SERCA
sarco/endoplasmic reticulum calcium-ATPase
SIC
sepsis-induced cardiomyopathy
Tfam
mitochondrial transcription factor A
UCPs
uncoupling proteins
Keywords
Heart
Inflammation
Metabolism
Mitochondria
Sepsis
Organ failure
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This article is part of a Special Issue entitled: The power of metabolism: Linking energy supply and demand to contractile function edited by Torsten Doenst, Michael Schwarzer and Christine Des Rosiers.
© 2018 Elsevier B.V.