Antimicrobial Susceptibility Study
In vitro activity of tedizolid against linezolid-resistant staphylococci and enterococci

https://doi.org/10.1016/j.diagmicrobio.2016.02.008Get rights and content

Highlights

  • Twenty-seven linezolid-resistant isolates of staphylococci and enterococci were studied.

  • Tedizolid MICs were ≥1 μg/mL and were 4- to 32-fold lower than linezolid MICs.

  • The most common resistance mechanism was the G2576T 23S rRNA gene mutation.

  • Mutations in rplC and/or rplD were also observed.

Abstract

The tedizolid MIC of 27 clinical isolates of linezolid-resistant staphylococci and enterococci was determined. Tedizolid MICs were ≥1 μg/mL and were 4- to 32-fold lower than those of linezolid. Linezolid resistance mechanisms included G2576T 23S rRNA gene and rplC and rplD mutations.

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