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Vol. 20. Issue 2.
Pages 214-215 (March - April 2016)
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Vol. 20. Issue 2.
Pages 214-215 (March - April 2016)
Clinical image
DOI: 10.1016/j.bjid.2015.11.005
Open Access
A strange infiltrative plaque on the face
Claudio Guarneria,
Corresponding author

Corresponding author.
, Uwe Wollinab, Anastasia Chokoevac, Torello Maria Lottid, Georgi Tcherneve
a Department of Clinical Experimental Medicine, Unit of Dermatology, at the University of Messina (Italy), C/O A.O.U. “G. Martino”, via Consolare Valeria, 1, 98125 Messina, Italy
b Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067 Dresden, Germany
c Onkoderma – Policlinic of Dermatology and Dermatologic Surgery, General Skobelev Nr 26, Sofia, Bulgaria
d University of Rome “G. Marconi”, Rome, Italy
e Policlinic for Dermatology and Venereology, Saint Kliment Ohridski University, Medical Faculty, University Hospital Lozenetz, Koziak Street 1, 1407 Sofia, Bulgaria
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A 64-year old lady, known to have hypertension and urolithiasis, presented with a 4-month history of a slowly growing, erythematous-edematous and infiltrative plaque with superficial desquamation, involving all the nose skin surface – except for the root – and both zigomatic areas up to the naso-labial folds (Fig. 1).

Fig. 1.

Erythematous-edematous-infiltrative plaque involving mainly the right side of the centro-facial region.


The patient came from a remote rural area of the south-eastern Sicily, and was a farmer. Personal and familiar anamnesis was negative for autoimmune diseases or skin disorders.

Routine blood exams were within normal limits; serum autoantibodies (antinuclear, anti-ENA, anti-JO1 and anti-Scl70) were negative. Nailfold capillaroscopy and chest X-ray examination were normal.

Histopathologic examination of a cutaneous biopsy revealed a granulomatous infiltrate in the dermis, consisting of lymphocytes, histiocytes, and multinuclear giant cells with hyperkeratotic overlying epidermis. A touch-imprint preparation of a skin specimen, showed Leishmania amastigotes, within the histiocytes as well as extracellularly.

Lupoid leishmanniasis (LL) is a rare form of cutaneous leishmaniasis (CL) showing a striking resemblance with some other granulomatous skin diseases of inflammatory or infectious origin.1

In fact, LL is characterized by a typical spreading of the initial lesion leading to an infiltrated plaque with undefined borders, whereas some papules and nodules, often with scaling, may become apparent, presenting a lupoid aspect. The involvement of suggestive areas, as in our case, may further complicate the differential diagnosis.2

Histopathological features are that of epithelioid granulomas, and the detection of amastigotes is often hollow, both in microscopy and cultures.3

It seems that in LL certain strains replicate inside the macrophage, so assuming their ability to evade intracellular destruction or a concomitant defect in the T-cell activation process.2,3Leishmania infantum, the most frequent causative agent of CL in our geographic area, have been rarely linked with LL.1,4

The patient received N-methylglucamine-antimoniate, 1mL twice-a-week intralesionally (total of 7 doses), with progressive improvement.

Conflicts of interest

The authors declare no conflicts of interest.

C. Guarneri, M. Vaccaro, S.P. Cannavò, F. Borgia, B. Guarneri.
Erythematous-edematous-infiltrative plaque on the face: cutaneous angio-lupoid leishmaniasis.
Eur J Dermatol, 12 (2002), pp. 597-599
A. Ul Bari, N. Raza.
Lupoid cutaneous leishmaniasis: a report of 16 cases.
Indian J Dermatol Venereol Leprol, 76 (2010), pp. 85
A. Khaled, S. Goucha, S. Trabelsi, R. Zermani, B. Fazaa.
Lupoid cutaneous leishmaniasis: a case report.
Dermatol Ther (Heidelb), 1 (2011), pp. 36-41
C. Guarneri, G. Tchernev, V. Bevelacqua, T. Lotti, G. Nunnari.
The unwelcome trio: HIV plus cutaneous and visceral leishmaniasis.
The Brazilian Journal of Infectious Diseases

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