Article information
Abstract
Meningococcal strains belonging to clonal complex cc60 are not associated with hypervirulent lineages and were never reported as causing disease in Latin American countries. This is the first report of a fatal meningitis case caused by a cc60 clonal complex meningococcus in Brazil. Despite the immune-compromised state of the patient, the fatal outcome here described shows the potential pathogenic behavior of strains belonging to this clonal complex and how compromised hosts can be susceptible to meningococcal infections even if the strain is not particularly invasive.
Keywords:
meningitis, meningococcal
meningococcal infections
Neisseria meningitidis
serogroup C
Full text is only available in PDF
References
[1.]
M.C. Maiden, J.A. Bygraves, E. Feil, et al.
Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.
Proc Natl Acad Sci U S A, 95 (1998), pp. 3140-3145
[2.]
R. Urwin, J.E. Russell, E.A. Thompson, et al.
Distribution of surface protein variants among hyperinvasive meningococci: implications for vaccine design.
Infect Immun, 72 (2004), pp. 5955-5962
[3.]
D.A. Caugant.
Population genetics and molecular epidemiology of Neisseria meningitidis.
Apmis, 106 (1998), pp. 505-525
[4.]
I. de Filippis, C.R. do Nascimento, M.B. Clementino, et al.
Rapid detection of Neisseria meningitidis in cerebrospinal fluid by one-step polymerase chain reaction of the nspA gene.
Diagn Microbiol Infect Dis, 51 (2005), pp. 85-90
[5.]
T.J. Falla, D.W. Crook, L.N. Brophy, et al.
PCR for capsular typing of Haemophilus influenzae.
J Clin Microbiol, 32 (1994), pp. 2382-2386
[6.]
P. Toikka, S. Nikkari, O. Ruuskanen, et al.
Pneumolysin PCR-based diagnosis of invasive pneumococcal infection in children.
J Clin Microbiol, 37 (1999), pp. 633-637
[7.]
A.J. Pollard, G. Probe, C. Trombley, et al.
Evaluation of a diagnostic polymerase chain reaction assay for Neisseria meningitidis in North America and field experience during an outbreak.
Arch Pathol Lab Med, 126 (2002), pp. 1209-1215
[8.]
L.F. Baethgen, L. Weidlich, C. Moraes, et al.
Epidemiology of meningococcal disease in southern Brazil from 1995 to 2003, and molecular characterization of Neisseria meningitidis using multilocus sequence typing.
Trop Med Int Health, 13 (2008), pp. 31-40
[9.]
I. de Filippis, C.F. de Andrade, L. Silva, et al.
PorA variable antigenic regions VR1, VR2, and VR3 of Neisseria meningitidis serogroups B and C isolated in Brazil from 1999 to 2004.
Infect Immun, 75 (2007), pp. 3683-3685
[10.]
I. de Filippis, A.C. Vicente.
Multilocus sequence typing and repetitive element-based polymerase chain reaction analysis of Neisseria meningitides isolates in Brazil reveal the emergence of 11 new sequence types genetically related to the ST-32 and ST-41/44 complexes and high prevalence of strains related to hypervirulent lineages.
Diagn Microbiol Infect Dis, 53 (2005), pp. 161-167
[11.]
A.P. de Lemos, T.Y. Yara, M.C. Gorla, et al.
Clonal distribution of invasive Neisseria meningitidis serogroup C strains circulating from 1976 to 2005 in greater São Paulo. Brazil.
J Clin Microbiol, 45 (2007), pp. 1266-1273
[12.]
A.P. Lemos, A.P. Brandão, M.C. Gorla, et al.
Phenotypic characterization of Neisseria meningitidis strains isolated from invasive disease in Brazil from 1990 to 2001.
J Med Microbiol, 55 (2006), pp. 751-757
Copyright © 2011. Elsevier Editora Ltda.. All rights reserved
