Journal Information
Vol. 19. Issue 5.
Pages 553 (September - October 2015)
Download PDF
More article options
Vol. 19. Issue 5.
Pages 553 (September - October 2015)
Clinical image
Open Access
Infectious mononucleosis skin rash without previous antibiotic use
Theocharis Koufakis
Corresponding author

Corresponding author at: 49 Ioustinianou Str., P.C. 41223, Larissa, Greece.
, Ioannis Gabranis
Department of Internal Medicine, General Hospital of Larissa, Larissa, Greece
This item has received

Under a Creative Commons license
Article information
Full Text
Download PDF
Figures (1)
Full Text

A 20-year-old female patient presented with fever, pharyngitis and lymphadenopathy. The diagnosis of infectious mononucleosis was established by high levels of IgM antibodies against the Epstein–Barr virus. Fifteen days after the onset of symptoms she developed a maculopapular generalized rash (Fig. 1), which resolved within a few days, without any special treatment. She had not received antibiotics or any other drug.

Fig. 1.

Maculopapular generalized rash on patient's back.


Patients with infectious mononucleosis may present with a non pruritic, faint rash during the course of the disease, which is believed to be caused directly by the virus. This is in contrast with the rash observed in patients who received beta-lactam antibiotics, mainly ampicillin or amoxicillin, which is associated with a hypersensitivity reaction to the antibiotic1 and it is usually pruritic and prolonged. Other, less common, skin manifestations of infectious mononucleosis include, among others, erythema nodosum, erythema multiforme, and urticaria.2 Our patient completely recovered within 3 months, with no complications.

Conflicts of interest

The authors declare no conflicts of interest.

I. Banerjee, S. Mondal, S. Sen, S.K. Tripathi, G. Banerjee.
Azithromycin-induced rash in a patient of infectious mononucleosis – a case report with review of literature.
J Clin Diagn Res, 8 (2014), pp. HD01-HD02
V. Di Lernia, Y. Mansouri.
Epstein–Barr virus and skin manifestations in childhood.
Int J Dermatol, 52 (2013), pp. 1177-1184
Copyright © 2015. Elsevier Editora Ltda.. All rights reserved
The Brazilian Journal of Infectious Diseases
Article options