Carbapenem-resistant Pseudomonas aeruginosa - clonal spread in Southern Brazil and in the State of Goiás

Scheffer, Mara Cristina; Gales, Ana Cristina; Barth, Afonso Luis; Carmo Filho, José Rodrigues do; Dalla-Costa, Libera Maria

doi:10.1016/S1413-8670(10)70101-X

The Brazilian Journal of Infectious Diseases

ISSN: 1413-8670

The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents.
The BJID is a bimonthly publication and one of the most influential journals in its field in Brazil and Latin America with a high impact factor. Since its inception it has garnered a growing share of the publishing market.

Indexed in:

Scopus, Medline, Directory of Open Access Journals (DOAJ), PubMed Central (PMC), Science Citation Index Expanded (SCIE), SCImago Journal Rank (SJR), SNIP

This study evaluated the clonal spread of carbapenem-resistant P. aeruginosa producing SPM-1 type metallo-β-lactamase (MBL), at the university hospital of Florianópolis, Santa Catarina, Brazil, compared to an epidemic clone previously reported, as well as strains collected in other three Brazilian states. Among the isolates, 17 (62%) were clonal and highly related to strains from other regions of Brazil. Six clonal strains harbored the blaSPM-1 gene. The finding of a unique SPM-1 producer clone suggests that its dissemination has contributed to the high resistance to carbapenems in Brazilian hospitals.

Keywords:

P. aeruginosa

carbapenem resistance

metallo-β-lactamase

Full text is only available in PDF

References

[1.]

A.C. Gales, L.C. Menezes, S. Silbert, H.S. Sader.

Dissemination in distinct Brazilian regions of an epidemic carbapenem-resistant Pseudomonas aeruginosa producing SPM metallo-beta-lactamase.

J Antimicrob Chemother, 52 (2003), pp. 699-702

http://dx.doi.org/10.1093/jac/dkg416 | Medline

[2.]

F.L. Pellegrino, N. Casali, K.R. Dos Santos, et al.

Pseudomonas aeruginosa epidemic strain carrying bla(SPM) metallo-beta-lactamase detected in Rio de Janeiro, Brazil.

J Chemother, 18 (2006), pp. 151-156

http://dx.doi.org/10.1179/joc.2006.18.2.151 | Medline

[3.]

L. Poirel, M. Magalhaes, M. Lopes, P. Nordmann.

Molecular analysis of metallo-beta-lactamase gene bla(SPM-1)-surrounding sequences from disseminated Pseudomonas aeruginosa isolates in Recife, Brazil.

Antimicrob Agents Chemother, 48 (2004), pp. 1406-1409

Medline

[4.]

R. Cipriano, V.V. Vieira, E.L. Fonseca, et al.

Coexistence of epidemic colistin-only-sensitive clones of Pseudomonas aeruginosa, including the blaSPM clone, spread in hospitals in a Brazilian Amazon City.

Microb Drug Resist, 13 (2007), pp. 142-146

http://dx.doi.org/10.1089/mdr.2007.708 | Medline

[5.]

CLSI. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically. (2006).

[6.]

F.C. Tenover, R.D. Arbeit, R.V. Goering, et al.

Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing.

J Clin Microbiol, 33 (1995), pp. 2233-2239

Medline

[7.]

A.P. Zavascki, P.B. Gaspareto, A.F. Martins, A.L. Goncalves, A.L. Barth.

Outbreak of carbapenem-resistant Pseudomonas aeruginosa producing SPM-1 metallo-{beta}-lactamase in a teaching hospital in southern Brazil.

J Antimicrob Chemother, 56 (2005), pp. 1148-1151

http://dx.doi.org/10.1093/jac/dki390 | Medline

[8.]

M.A. Toleman, A.M. Simm, T.A. Murphy, et al.

Molecular characterization of SPM-1, a novel metallo-beta-lactamase isolated in Latin America: report from the SENTRY antimicrobial surveillance programme.

J Antimicrob Chemother, 50 (2002), pp. 673-679

Medline

Download PDF

Indexed in:

Follow us:

Subscribe to our newsletter